Research in the Crispino lab is focused on investigating the regulatory mechanisms governing normal and malignant blood cell development, with an emphasis on understanding the growth of erythroid cells (red blood cells) and megakaryocytes (platelet-producing cells). In addition, we are greatly interested in learning how changes in normal essential regulatory molecules lead to human blood diseases, including leukemias, myelodysplastic syndromes (MDS) and myeloproliferative diseases (MPD).