Clinical and Translational Research 

Ram Yogev, MD - Deputy Director for Research - Clinical Sciences, CMRC, Director, Clinical and Translational Research Program, CMRC   

Our Mission

The mission of the Clinical and Translation Research Program (CTR) is to provide a synergistic mechanism to accelerate the delivery of translational and clinical research to our patients. The CTR Program provides support to multidisciplinary teams from ALL the departments at Children’s Memorial Hospital and Children’s Memorial Research Center (CMRC), who are involved in translational and clinical research.

Under the leadership of Ram Yogev, MD, and with over 135 members, the program provides a home for investigators engaged in both clinical trials and bench-to-bedside research regardless of funding source. Complementing the core programs and centers of Children’s Memorial Research Center and working in tandem with the Clinical Research Unit (CRU), the Research Pharmacy, the Biostatistics Research Core (BRC) and Clinical Trials Research Center (CTRC), the CTR Program provides support to researchers as they progress from innovation to patient treatment.  

 Our Goal 

Our goal is to develop a culture of research by fostering collaboration, training researchers, providing institutional support, expanding resources, and coordinating services for the researcher. The CTR program includes all clinical and translational trials conducted by CMRC-affiliated investigators, whether investigator-initiated or not, providing the needed infrastructure.  Sponsors may include the NIH, pharmaceutical industry, philanthropic or other organizations. 
The CTR works to 

  • Expand the breadth of clinical and translational studies conducted at CMH and to assure the highest  scientific   standard for all such studies.  
  • Improve upon the current infrastructure for conducting clinical research trials.  
  • Encourage the development of multi-center patient groups in pediatric sub-specialty areas for use in multi-center therapeutic trials.  This is a crucial asset for the CMRC translational initiatives, serving as a vital bridge between drug/device discovery in CMRC laboratories and the needs of our pediatric populations.  
  • Train residents, fellows and other investigators in the experimental and biostatistical methodology through a recently developed educational program.   Topics covered include study design, conduct, and analysis of clinical trials related to pediatric and adolescent disorders as well as research ethics and the protection of human subjects.  
  • Help investigators develop and evaluate treatment and prevention measures for pediatric disorders and adult-onset disorders with childhood antecedents (e.g. stroke, epilepsy).  By giving our patients and other children an opportunity to participate in clinical trials of novel or modified therapies for a range of serious childhood disorders, we ultimately will be able to give all children the benefit of new, better and less toxic medications.  As scientists reveal new information leading to innovations in detecting and treating childhood diseases, we will be able to test these promising new treatments and ensure they reach those who most need them.   




Our Program Leaders  

 Heirarchary FlowChart