CMRC Children's Memorial Research Center
CADIS

Brief Summary of the Childhood Atopic Dermatitis Impact Scale (CADIS)

To measure the effects of atopic dermatitis on the quality of life of young children (under the age of 6 years) and their families, we developed a 45-item quality-of-life instrument, the Childhood Atopic Dermatitis Impact Scale (CADIS). The CADIS was developed from a comprehensive conceptual framework based on input from parents and expert clinicians. The instrument has two dimensions with five domains: child dimensions (symptoms and activity limitation/behavior) and parent dimensions (family/social function, sleep, and emotions) yielding a total summary score between 0-180. See the table below for CADIS scoring information. The psychometric properties of the CADIS were evaluated, and details are included in the references listed below.

 
Mild*
N=62
Moderate*
N=173
Severe*
N=35
Score
Range
Number of Items
Corresponding Item in CADIS
Child: Symptoms
17.27 (SD=5.96)
21.95 (SD=6.26)
29.41 (SD=4.15)
0-28
7
1, 6, 9, 10, 12, 14, 17
Child: Activity Limitation
13.79 (SD=4.26)
16.39 (SD=5.20)
24.46 (SD=5.91)
0-36
9
2, 21, 22, 24, 27, 29, 34, 41, 43
Parent: Family and Social Function
10.89 (SD=3.02)
13.81 (SD=6.10)
19.97 (SD=7.45)
0-36
9
4, 5, 7, 8, 11, 20, 30, 40, 45
Parent: Sleep
5.10
(SD=2.42)
6.49 (SD=2.95)
10.06 (SD=3.10)
0-12
3
3, 31, 36
Parent: Emotion
33.70 (SD=10.93)
40.97 (SD=12.93)
51.61 (SD=10.49)
0-68
17
13, 15, 16, 18, 19, 23, 25, 26, 28, 32, 33, 35, 37, 38, 39, 42, 44
CADIS total score
80.75 (SD=21.32)
99.61 (SD=28.55)
135.51 (SD=23.10)
0-180
45
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The CADIS-45 Scores for Disease Severity* and Scoring System
 
*Objective SCORAD index scores categorized into mild, moderate, and severe disease.
 

 

 
References:
Chamlin SL, Cella D, Lai JS, Frieden IJ, Williams ML, Mancini AJ, Chren, MM. Childhood Atopic Dermatitis Impact Scale (CADIS): Reliability, Discriminative and Concurrent Validity, and Responsiveness. In preparation.

Chamlin SL, Cella D, Frieden IJ, Williams ML, Mancini AJ, Lai JS, Chren MM. Development of the Childhood Atopic Dermatitis Impact Scale (CADIS): Initial Validation of a Quality-of-Life Measure for Young Children with Atopic Dermatitis and their Families. J Invest Dermatol 2005;125(6):1106-1111.

Chamlin SL, Mattson CL, Frieden IJ, Williams ML, Mancini AJ, Cella D, Chren MM. The Price of Pruritus: Sleep disturbance and cosleeping in atopic dermatitis. Arch Pediatr Adolesc Med 2005;159:745-750.

Chamlin SL, Frieden IJ, Williams ML, Chren MM. Effects of atopic dermatitis on young American children and their families. Pediatrics 2004;114:607-611.