Profile

Anne H. Rowley, MD

Address:

2300 Children's Plaza
Box 20
Chicago, IL 60614
Phone: (773) 880-4187

Clinical Appointment
	Attending physician, Division of Infectious Diseases

Academic Appointment
	Professor of Pediatrics, Northwestern University's Feinberg School of Medicine

Clinical Interests
	Kawasaki disease, pediatric infections

Mentoring Interests
	Kawasaki Disease

Research Interests

Dr. Rowley’s research interests focus on the etiology, pathogenesis, and treatment of Kawasaki Disease (KD), an acute vasculitis of young childhood that is the most common cause of acquired heart disease in developed nations and that may be fatal. She is the principal investigator on the NIH-funded study “The Pathogenesis of Kawasaki Disease” with these specific aims: identify the cell and tissue types in which inclusion bodies form in acute KD, and search these cells/tissues for microbial elements by TEM, identify the nucleic acid/protein contents of KD cytoplasmic inclusion bodies, and determine whether dysregulation of members of the TNF- and TNF-receptor superfamily contribute to KD vasculopathy. She is a Co-Investigator on the NIH-sponsored project “Bronchial Epithelial Cell Cultures and Kawasaki Disease”. The major goals of this proposal are to determine if clinical respiratory samples from acute KD patients infect ciliated bronchial epithelial cell cultures in vitro and to use sequence-independent amplification techniques to amplify, clone, and sequence novel nucleic acid sequences from the cell-free supernatant of the cultures. In her laboratory, Dr. Rowley and her research team have made an important discovery, suggesting that there is indeed a viral cause of Kawasaki Disease that points to a single respiratory virus or a closely related group of viruses as the cause. To read more of Dr. Rowley’s current research, click here.

Link to Clinical Trials

Publications

Clinical Link

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