Leon G. Epstein, MD

 Leon Epstein 



2300 Children's Plaza
Box 51
Chicago, IL 60614
Phone: (773) 880-4352


Clinical Appointment
       Division Head, Neurology, Children's Memorial Hospital

Academic Appointment
      Derry A. and Donald L. Shoemaker Professor of Pediatric Neurology
Associate Chair for Research, Department of Pediatrics, Northwestern University's Feinberg School of Medicine
Professor of Pediatrics and Neurology, Northwestern University's Feinberg School of Medicine

Clinical Interests

Viral disorders on the nervous system; migraine headaches; additional neurological consultations for complex disorders 

Mentoring Interests 

 Neurovirology and viral pathogensis.

Research Interests
     Dr. Epstein’s laboratory is engaged in the study of the impact of viral infections on the developing nervous system. Currently we are investigating the role of Human Herpesvirus 6, and 7 (HHV-6 and HHV-7) as potential causes of hippocampal injury during febrile status epilpepticus (FSE). Dr. Epstein is a co-investigator and the study neurovirologist for the five year NINDS funded multicenter longitudinal FEBSTAT study of 200 children with FSE. To date we have found that HHV-6B is the most common cause of FSE in children accounting for nearly 25% of the infants that present with FSE. This longitudinal study will allow us to determine if FSE caused by HHV-6B or HHV-7 is more likely to result in mesial temporal sclerosis and temporal lobe seizures. Intractable temporal lobe seizures are the most common reason for epilepsy surgery in adolescents and young adults. If HHV-6B or HHV-7 prove to be responsible for hippocampal damage it is possible that the injury could be prevented by treatment with anti-viral or anti-infammatory medications at the time of presentation with FSE


Clinical Link

Curriculum Vitae    

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