Profile

  Seth J. Corey, MD, MPH  
     Seth Corey        

   


Address:


2300 Children's Plaza
Box 30
Chicago, IL 60614
Phone: (773) 880-4562


Email:

     

Clinical Appointment
     Attending physician, Hematology/Oncology

Academic Appointment
   

Director of Oncology Research
Co-director of the Hematology/Oncology Fellowship Program
Sharon B. Murphy, MD, and Steven T. Rosen, MD, Professor of Cancer Biology and Chemotherapy
Professor of Pediatrics, Northwestern University's Feinberg School of Medicine

Clinical Interests
      Neutropenia, inherited bone marrow failure syndromes, acute myeloid leukemia, juvenile myelomonocytic leukemia, myelodysplastic syndromes, chronic myeloid leukemia, ataxia telangiectasia and related DNA breakage syndromes

Mentoring Areas of Interest
  Cell signaling, Drug development, Cytoskeletal biology, Cancer biology, Systems biology 
 
Research Interests
     Our laboratory studies oncogene signaling. Src family protein kinases and PI 3’kinase regulate a variety of critical cellular functions, such as proliferation and cytoskeletal reorganization. To do this, our laboratory employs a wide range of molecular and cellular approaches, including molecular biology, confocal microscopy, RNAi, and systems biology. Diseases studied include myeloid leukemias, breast cancer, bone tumors, and diabetes.

1. More specifically, we are establishing the contributions made by the Src kinase Lyn in blood cell production (hematopoiesis). By examining how the G-CSF (granulocyte colony stimulating factor) Receptor drives the production of neutrophils, we found that the Src kinase Lyn is indispensable. One of Lyn’s downstream effectors is PI 3’kinase, which in turn activates the serine kinase Akt. We found that Lyn and PI 3’kinase are excessively active in several types of leukemia. Leukemia results from two major catatstrophic events: unregulated growth and survival and a block in differentiation. We are currently investigating how aberrant Lyn and PI 3’kinaser activities perturb each behavior.

Children who have congenital neutropenia and are treated with G-CSF frequently develop acute leukemia in association with a mutated G-CSF Receptor. This receptor is differentiation-defective. We are looking at the mechanisms by which this receptor drives leukemogenesis. This serves as a model for a more common form of adult leukemia.

2. We discovered a new cytoskeletal protein in a yeast two hybrid screening with Src kinase Lyn as bait. This protein is called Cdc42-interacting protein #4, and it is a member of a new family of proteins (F-BAR proteins). We have made a knock-out of this mouse and have employed siRNA to validate our findings that CIP4 contributes to membrane remodeling, receptor endocytosis, and cellular motility.

3. Through discovering functional interactions like Lyn and PI 3’kinase and new components such as CIP4, we realized several years ago that we needed to use new approaches to further unravel the mysteries of cell signaling. With the goal of simplifying the complexity of biological systems, we began a collaboration with computer scientist, chemical engineers, and mathematicians to model hematopoiesis. We are also applying this approach to design multi-drug targeted therapies in leukemia.
        

Corey Laboratory Link
Publications
Clinical Link  

Curriculum Vitae

 

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