Jacek Topczewski, Ph.D.


Assistant Professor of Pediatrics, Northwestern University, Feinberg School of Medicine, Developmental Biology Program

2300 Children's Plaza
Box 204 Room C.421F
Chicago, IL 60614
Phone: (773) 755-6545
Fax: (773) 755-6385 










Institute of Biochemistry and Biophysics, Polish Academy of Science




Warsaw University


Research Interests 


Role of Wnt signaling in zebrafish cartilage morphogenesis.
Function of Glypicans (heparan sulfate proteoglycans) in zebrafish development.

Lab Affiliations


Topczewski lab


Recent Publications  


Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. (June, 2008). Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology: 92-101.

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M. (October, 2007). Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development: 3461-3271.

Inbal A, Topczewski J, Solnica-Krezel L (November, 2006). Targeted gene expression in the zebrafish prechordal plate. Genesis: 584-588.

Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J and Hendrix MJC (August, 2006). Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness . Nat Med: 925 - 932.

Lin F, Sepich DS, Chen S, Topczewski J, Yin C, Solnica-Krezel L, Hamm H. (June, 2005). Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol: 777-787.

Cooper MS, Szeto DP, Sommers-Herivel G, Topczewski J, Solnica-Krezel L, Kang HC, Johnson I, Kimelman D. (February, 2005). Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP.. Dev Dyn: 359-368.

Ninkovic J, Tallafuss A, Leucht C, Topczewski J, Tannhauser B, Solnica-Krezel L, Bally-Cuif L (January, 2005). Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development: 75-88.

Topczewska JM, Topczewski J, Shostak A, Solnica-Krezel L, and Hogan BLM (May, 2003). Developmentally regulated expression of two members of the Nrap family in zebrafish. Gene Expr Patterns: 169-171.

Jessen JR, Topczewski J, Bingham S, Sepich DS, Marlow F, Chandrasekhar A, Solnica-Krezel L (August, 2002). Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements.. Nat Cell Biol.: 610-615.

Marlow F, Topczewski J, Sepich D, Solnica-Krezel L (June, 2002). Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol: 876-884.

Topczewska JM, Topczewski J, Shostak A, Kume T, Solnica-Krezel L, Hogan BL (September, 2001). The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes Dev: 2483-2493.

Topczewski J, Sepich DS, Myers DC, Walker C, Amores A, Lele Z, Hammerschmidt M, Postlethwait J, Solnica-Krezel L (August, 2001). The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension.. Dev Cell: 251-264. 


Professional Service


2005 - Present Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine




Integrated Graduate Program (IGP)
Northwestern University Institute for Neuroscience (NUIN)
Topczewski Laboratory
Zebrafish Information Network

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