Hui-Ju Tsai


Assistant Professor
Investigator, Child Health Research

2300 Children's Plaza, Box 157
Chicago, IL 60614
Phone: (312) 573-7735
Fax: (312) 573-7825










University of Pittsburgh




Yale University, USA


Work Experience 






2006 - Present 

Assistant Professor 

The Smith Child Health Research Program, Children's Memorial Hospital/Research Center; and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago.


2004 - 2006 

Postdoctoral fellow 

Department of Medicine, University of California, San Francisco, San Francisco, CA.


1997 - 2000 


 Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan.


Research Interests 


statistical genetics
genetic epidemiology
preterm birth
food allergy
gene mapping


Recent Publications


Zhang S, Liu X, Yu Y, Hong X, Christoffel KK, Wang B, Tsai HJ, Li Z, Liu X, Tang G, Xing H, Brickman WJ, Zimmerman D, Xu X, Wang X. (2009). Genetic and Environmental Contributions to Phenotypic Components of Metabolic Syndrome: A Population-based Twin Study. Obesity (Silver Spring). 2009 Apr 30. [Epub ahead of print].

Tsai HJ, Yu Y, Zhang S, Pearson C, Ortiz K, Xu X, Bauchner H, Zuckerman B, Wang X. (2009). Association of Genetic Ancestry with Preterm Delivery and Related Traits among African American Mothers. Am J Obstet Gynecol. 2009 May 14 [Epub ahead of print].

Liu X, Zhang SC, Tsai HJ, Hong XM, Wang BY, Fang YP, Liu X, Pongracic J, Wang X. (2009). Genetic and Environmental Contributions to Allergen Sensitization in a Chinese Twin Study. Clinical and Experimental Allergy (in press).

Yu Y, Tsai HJ, Liu X, Zhang S, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Xu X, Wang X. (2009). The interaction between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery. Human Genetics 2009 Jan;124(6):659-68.

Hong X, Zhou H, Tsai HJ, Wang X, Liu X, Wang B, Xu X, Xu X. (2009). Cysteinyl Leukotriene Receptor 1 Gene Variation and Risk of Asthma in Chinese Population.. Eur Respir J. 2009 Jan;124(6):42-8.

Tsai HJ, Kumar R, Pongracic J, Liu X, Story R, Yu Y, Deanna C, Costello J, Schroeder A, Fang Y, O'Gorman M, Wang X. (2009). Familial aggregation of food allergy and sensitization to food allergens: A family-based study. Clinical and Experimental Allergy. 2009 Jan;39(1):101-9.

Hong X, Tsai HJ, Liu X, Li Z, Liu X, Tang G, Xing H, Yang J, Wang B, Feng Y, Xu X, Xu X, Wang X. (2008). Large-Scale Genome-Wide Linkage Analysis to Map Loci Linked to Stature in Chinese population.. Clin Endocrinol Metab. 2008 Nov;93(11):4511-8.

Aberg K, Sun G, Smelser D, Indugula SR, Tsai HJ, Steele MS, Tuitele J, Deka R, McGarvey ST, Weeks DE. (2008). Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.. Hum Biol. 2008 Apr;80(2):99-123..

Tsai HJ, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield PG, Xu X, Wang X. (2008). Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways.. Hum Genet. 2008 May;123(4):359-69..

Battle NC, Choudhry S, Tsai HJ, Eng C, Kumar G, Beckman K, et al. (2007). Ethnic specific gene-gene interaction between IL-13 and IL-4R among African American Asthmatics.. Am J Respir Crit Care Med. 2007 May;175(9):881-7..

Naqvi M, Choudhry S, Tsai HJ, Thyne S, Navarro D, et al. (2007). Association between immunoglobulin E levels and asthma severity among African American, Mexican and Puerto Rican asthmatics.. J Allergy Clin Immunol. 2007 Jul;120(1):137-43..

Naqvi M, Thyne S, Choudhry S, Tsai HJ, Navarro D, Castro RA, et al. (2007). Ethnic-specific Differences in Bronchodilator Responsiveness Among African Americans, Puerto Ricans, and Mexicans with Asthma.. J Asthma. 2007 Oct;44(8):639-48..

Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, et al. (2006). Population Stratification Confounds Genetic Association Studies of Asthma among Latino Americans.. Hum Genet. 2006 Jan;118(5):652-64..

Tsai HJ, Kho J, Shaikh N, Choudhry S, Naqvi M, Navarro D, et al. (2006). Admixture-Matched Case-Control Study: A Practical Approach for Genetic Association Studies in Admixed Populations.. Hum Genet. 2006 Jan;118(5):626-39..

Tsai HJ, Weeks DE. (2006). Comparison of methods incorporating covariates into affected sib pair linkage analysis.. Genet Epidemiol. 2006 Jan;30(1):77-93..

Tsai HJ, Shaikh N, Kho JY, Battle N, et al. (2006). 2-Adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics.. Hum Genet. 2006 Jun;119 (5):547-57..

Tsai YJ, Choudhry S, Kho J, Beckman K, Tsai HJ, Navarro D, et al. (2006). The PTGDR gene is not associated with asthma in 3 ethnically diverse populations.. J Allergy Clin Immunol. 2006 Dec;118(6):1242-8..

Choudhry S, Avila PC, Nazario S, Ung N, Kho J, Rodriguez-Santana JR, Casal J, Tsai HJ, Torres A, Ziv E, et al. (2005). CD14-Tobacco Gene-Environment Interaction Modify Asthma Severity and Immunoglobulin E Levels in Latino Asthmatics.. Am J Respir Crit Care Med. 2005 Jul;172(2):173-82..

Burchard EG, Borrell LN, Choudhry S, Naqvi M, Tsai HJ, Rodriguez-Santana JR, Chapela R, Rogers SD, et al. (2005). Latino Populations: A unique contribution to the study of Race, Genetics and Social Environment in Epidemiologic Research.. Am J Public Health. 2005 Dec;95(12):2161-8..

Tsai HJ, Choudhry S, Naqvi M, Rodriguez-Cintron W, Burchard EG, Ziv E. (2005). Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations.. Hum Genet. 2005 Dec;118(3-4):424-33..

Reck BH, Mukhopadhyay N, Tsai HJ, Weeks DE. (2005). Analysis of alcohol dependence phenotype on the COGA families using covariates to detect linkage.. BMC Genet. 2005 Dec;6 Suppl 1:S143..

Weeks DE, Conley YP, Tsai HJ, Mah TS, Schmidt S, Postel EA, Agarwal A, Haines JL, Pericak-Vance MA, Rosenfeld PJ, Paul TO, Eller AW, Morse LS, Dailey JP, Ferrell RE, Gorin MB. (2004). Age-Related Maculopathy: A Genomewide Scan with Continued Evidence of Susceptibility Loci within the 1q31, 10q26, and 17q25 Regions.. Am J Hum Genet. 2004 Aug; 75(2): 174-89..

Tsai HJ, Sun G, Smelser D, Viali S, Tufa J, Jin L, Weeks DE, McGarvey ST, Deka R. (2004). Distribution of genome-wide linkage disequilibrium based on microsatellite loci in the Samoan population.. Human Genomics. 2004 Aug; 1(5):327-334..

Wu KD, Hsiao CF, Ho LT, Sheu WH, Pei D, Chuang LM, Curb D, Chen YD, Tsai HJ, Dzau VJ, Cox D, Tai TY. (2002). Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study.. Hypertens Res. 2002 Jul; 25(4):529-36..

Weeks DE, Conley YP, Tsai HJ, Mah TS, Rosenfeld PJ, Paul TO, Eller AW, Morse LS, Dailey JP, Ferrell RE, Gorin MB. (2001). Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions.. Am J Ophthalmol. 2001 Nov; 132(5): 682-92.

Tsai HJ, Sun G, Weeks DE, Kaushal R, Wolujewicz M, McGarvey ST, Tufa J, Viali S, Deka R. (2001). Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association.. Am J Hum Genet. 2001 Dec; 69(6):1236-44.




2005 - Thesis/Dissertation Award offered by Delta Omega Honor Society, University of Pittsburgh

2005 - James V. Neel Young Investigator Award offered by IGES

2004 - Outstanding Student Award offered by University of Pittsburgh

2004 - Elected Full Member of Delta Omega Honor Society

2002 - Delta Omega - Omicron Chapter Annual Poster Award

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