Assistant Professor of Pediatrics, Northwestern University, Feinberg School of Medicine, Developmental Biology Program 2300 Children's Plaza Box 204 Room C.421F Chicago, IL 60614 Phone: (773) 755-6545 Fax: (773) 755-6385

Year		Degree		Institution
1996		Ph.D.		Institute of Biochemistry and Biophysics, Polish Academy of Science
1988		M.Sc.		Warsaw University

Role of Wnt signaling in zebrafish cartilage morphogenesis.
Function of Glypicans (heparan sulfate proteoglycans) in zebrafish development.

Topczewski lab

Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. (June, 2008). Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology: 92-101.

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M. (October, 2007). Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development: 3461-3271.

Inbal A, Topczewski J, Solnica-Krezel L (November, 2006). Targeted gene expression in the zebrafish prechordal plate. Genesis: 584-588.

Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J and Hendrix MJC (August, 2006). Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness . Nat Med: 925 - 932.

Lin F, Sepich DS, Chen S, Topczewski J, Yin C, Solnica-Krezel L, Hamm H. (June, 2005). Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol: 777-787.

Cooper MS, Szeto DP, Sommers-Herivel G, Topczewski J, Solnica-Krezel L, Kang HC, Johnson I, Kimelman D. (February, 2005). Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP.. Dev Dyn: 359-368.

Ninkovic J, Tallafuss A, Leucht C, Topczewski J, Tannhauser B, Solnica-Krezel L, Bally-Cuif L (January, 2005). Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development: 75-88.

Topczewska JM, Topczewski J, Shostak A, Solnica-Krezel L, and Hogan BLM (May, 2003). Developmentally regulated expression of two members of the Nrap family in zebrafish. Gene Expr Patterns: 169-171.

Jessen JR, Topczewski J, Bingham S, Sepich DS, Marlow F, Chandrasekhar A, Solnica-Krezel L (August, 2002). Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements.. Nat Cell Biol.: 610-615.

Marlow F, Topczewski J, Sepich D, Solnica-Krezel L (June, 2002). Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol: 876-884.

Topczewska JM, Topczewski J, Shostak A, Kume T, Solnica-Krezel L, Hogan BL (September, 2001). The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes Dev: 2483-2493.

Topczewski J, Sepich DS, Myers DC, Walker C, Amores A, Lele Z, Hammerschmidt M, Postlethwait J, Solnica-Krezel L (August, 2001). The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension.. Dev Cell: 251-264.

2005 - Present		Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine

Integrated Graduate Program (IGP)
Northwestern University Institute for Neuroscience (NUIN)
Topczewski Laboratory
Zebrafish Information Network

Last Updated: May 30 2008 11:01AM