CMRC Children's Memorial Research Center
Profile


Elisabeth A. Seftor
 Director: NIH/NCI Tumor Microenvironment Training Course



Children's Memorial Research Center
2430 N. Halsted St Room 477
Chicago , IL 60614
Phone: (773) 755-6366
Fax: (773) 755-6594


Education
Year Degree Institution
1975 Bachelor of Science in Cellular Molecular Biology California State University, Northridge

Work Experience
Period Description Organization
June 2004 - Present Senior Research Scientist, Children's Memorial Research Center Children's Memorial Hospital
August 1996 - May 2004 Senior Research Specialist Dept of Anatomy & Cell Biology University of Iowa
December 1993 - August 1996 Senior Research Associate, Pediatric Research Institute, Dept. of Pediatrics Saint Louis University
July 1983 - August 1993 Senior Research Specialist, Dept of Anatomy and Dept of Biochemistry University of Arizona
August 1977 - July 1983 Staff Research Associate II, Dept of Biology and Dept of Microbiology University of California, Los Angeles
July 1975 - June 1977 Staff Research Associate I, Dept of Microbiology & Immunology University of California, Berkeley

Research Interests
As part of the Mary Hendrix research team we have recently embarked on the classification and molecular profiling of tumors, especially cutaneous and ocular melanomas, based on differential gene expression (microarray analysis). Our findings based on the molecular signature of aggressive melanoma cells indicate the expression of multiple phenotypes, which appears to mimic a multi-potent, embryonic-like phenotype. One example of this tumor cell plasticity was seen in the ability of aggressive melanoma cells (but not poorly aggressive cells) to express endothelial cell-specific markers and participate in vasculogenic mimicry. The aggressive tumor cells also demonstrated the ability of deposit “molecular cues” into the basement membrane matrix of their environment that can subsequently induce poorly aggressive cells to participate in vasculogenic mimicry and express endothelial cell-specific markers. The observation that aggressive tumor cells can express multiple molecular phenotypes should lead to the development of new diagnostic markers and therapeutic targets for clinical intervention of cancer.

Lab Affiliations
Hendrix Laboratory
Robert H Lurie Comprehensive Cancer Center

Recent Publications
Hendrix MJC, Luo J, Seftor EA, Sharma N, Heidger PM Jr, Cohen MB, Bhatty R, Chunthapong J, Seftor REB and Lubaroff DM (2007). Epithelial-mesenchymal interactions in prostatic tumor cell plasticity in RL Ablin and MD Mason, Cancer Metastasis – Biology and Treatment : 10:127-141. Netherlands:Kluwer Academic Publishers.

Postovit LM, Costa FF, Bischof JM, Seftor EA, Wen B, Seftor REB, Feinberg AP, Soares MB and Hendrix MJC (2007). The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells.. J Cell Biochem: 101:908-917.
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Hendrix MJC, Seftor EA, Seftor REB, Kasemeier-Kulesa J, Kulesa PM and Postovit LM (2007). Reprogramming metastatic tumor cells with embryonic microenvironments. . Nature Rev Cancer: 7:246-255.
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Postovit LM, Seftor EA, Seftor REB and Hendrix MJC (2007). Targeting Nodal in malignant melanoma cells.. Expert Opinion Ther Targets : 11:497-505.
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Abbott DE, Postovit LM, Seftor EA, Margaryan NV, Seftor REB and Hendrix MJC (2007). Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targets. . Stem Cell Rev : 3:68-78.
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Postovit LM, Seftor EA, Seftor REB and Hendrix MJC (August, 2006). Influence of the microenvironment on melanoma cell fate determination and phenotype. Cancer Research: 66: 7833-7836..
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Postovit LM*, Seftor EA*, Seftor REB and Hendrix MJC (*equal authorship). (March, 2006). A 3-D Model to Study the Epigenetic Effects Induced by the Microenvironment of Human Embryonic Stem Cells. . Stem Cells : 24:501-505. Epub 2005 Nov 17. .
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Seftor EA, Meltzer PS, Kirschmann DA, Margaryan NV, Nickoloff BJ, Seftor REB and Hendrix MJC (March, 2006). The epigenetic reprogramming of poorly aggressive melanoma by a metastatic melanoma microenvironment: Biomechanical role of matrix deformability.. J Cell Mol Med : 10:174-196.
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Norwood LE, Moss TJ, Margaryan NV, Cook SL, Wright L, Seftor EA, Hendrix MJ, Kirschmann DA, Wallrath LL (2006). A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion. J Biol Chem: 281: 18668-18676.
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Hess AR, Seftor EA, Gruman LM, Kinch MS, Seftor REB, and Hendrix MJC (2006). VE-cadherin regulates EphA2 by in aggressive melanoma cells through a novel signaling pathway: Implications for vasculogenic mimicry.. Cancer Biology & Therapy: 5:e1-e6 (Cover Illustration).
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Kulesa PM, Kasemeier-Kulesa JC, Teddy JM Margaryan NV, Seftor EA, Seftor REB and Hendrix MJC (2006). Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. . Proceedings National Academy Sciences: 103:3752-3757. Epub 2006 Feb 27.
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Rojas JD, Sennoune SR, Maiti D, Bakunts K, Reuveni M, Sanka SC, Martinez GM, Seftor EA, Meininger CJ, Wu G, Wesson DE, Hendrix MJC and Martinez-Zaguilan R (2006). Vacuolar type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells. J Physiol: Heart Circulation Physiology: 291(3):H1147-57.

Hendrix MJC, Seftor EA and Seftor REB (2006). Vasculogenic mimicry: Angiogenesis in Disguise? in Forough R, New Frontiers in Angiogenesis: 97-109. Springer, Dordrecht .

Bailey CM, Khalkhali-Ellis Z, Seftor, EA and Hendrix MJC (2006). The biological functions of maspin. J Cell Physiol. (Art Pardee special issue): 209:617-624.
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Lee, MJ, Seftor EA, Bonde G, Cornell R, Hendrix MJC (2005). The fate of human malignant melanoma cells transplanted into zebrafish embryos: Assessment of migra-tion and cell division in the absence of tumor formation.. Developmental Dynamics: 233:1560-1570.
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Hess AR, Postovit LM, Margaryan NV, Seftor EA, Schneider GB, Seftor REB, Nickoloff BJ and Hendrix MJC (2005). Focal adhesion kinase promotes aggressive melanoma phenotype. . Cancer Research : 65:9851-9860 (Highlighted).

Seftor EA, Brown K, Chin L, Kirschmann DA, Wheaton WW, Protopopov A, Feng B, Balagurunathan Y, Trent JM, Nickoloff BJ, Seftor REB and Hendrix MJC (2005). Epigenetic transformation of normal melanocytes by a metastatic melanoma microenvironment. . Cancer Research : 65:10164-10169 (Highlighted).
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Payne SL, Fogelgren B, Hess AR, Seftor EA, Wiley EL, Fong SFT, Csiszar K, Hendrix MJC and Kirschmann DA (2005). Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. . Cancer Research : 65:11429-11436.
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Seftor EA, Meltzer PS, Kirschmann DA, Margaryan NV, Seftor REB and Hendrix MJC (2005). The epigenetic influence of the tumor microenvironment on melanoma plasticity. in GG Meadows, Integration/Interaction of Oncogenic Growth: 47-63. Netherlands: Kluwer Academic Publishers.

Hendrix MJC, Seftor EA and Seftor REB (2005). The plasticity of melanoma cells and associated clinical implications in V Hearing and SPL Leong, Melanocytes to Melanoma: The progression to malignancy: 535-552. USA: Humana Press.
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Seftor REB, Seftor EA, Hess AR and Hendrix MJC (2004). The role of the vasculogenic phenotype and its associated extracellular matrix in tumor progression: Implications for immune surveillance. . Clinical & Applied Immunology Reviews : 3:263-276.

van der Schaft DWJ, Seftor REB, Seftor EA, Hess AR, Gruman LM, Kirschmann DA, Yokoyama Y, Griffioen AW and Hendrix MJC (2004). Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. Journal of the National Cancer Institute: 96: 1473-1477.
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Sood AK, Fletcher MS, Coffin JE, Yang M, Seftor EA, Gruman LM, Gershenson DM and Hendrix MJC (2004). Functional roles of matrix metalloproteinases in ovarian tumor cell plasticity. Amer J Obstet Gyn : 190:899-909.
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Qin J-Z, Stennett L, Bacon P, Bodner B, Hendrix MJC, Seftor REB, Seftor EA, Margaryan NV, Pollock P, Curtis A, Trent JM, Bennett F,, Miele L and Nickoloff BJ (2004). p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. . Molecular Cancer Therapeutics: 3:895-902.
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Hendrix MJC, Seftor EA, Meltzer PS, Hess AR, Gruman LM, Nickoloff BJ, Miele L, Sheriff DD and Schatteman GC, Bourdon MA and Seftor REB (2004). The stem cell plasticity of aggressive melanoma tumor cells in ES Sell, Germinal Stem Cells: 27:297-306. USA: Humana Press .

Hendrix MJC, Seftor EA, Hess AR and Seftor REB (2003). The molecular plasticity of human melanoma cells. . Oncogene : 22:3070-3075.
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Hendrix MJC, Seftor EA, Hess AR and Seftor REB (2003). Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nature Reviews Cancer: 3:411-421.
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Hendrix MJC, Seftor EA, Kirschmann DA, Quaranta V and Seftor REB (2003). Remodeling the microenvironment by aggressive melanoma tumor cells. . Annals NY Academy of Science: 995:151-161.

Odero-Marah V, Khalkhali-Ellis Z, Seftor EA, Seftor REB and Hendrix MJC (2003). Maspin regulates cell motility through the RAC signaling pathway. Cancer Biology & Therapy: 2:67-72.
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Hess AR, Seftor EA, Seftor REB and Hendrix MJC (2003). Phosphoinositide 3-kinase regulates membrane type-1 matrix metalloproteinase (MT1-MMP) and MMP-2 activity during melanoma cell vasculogenic mimcry. Cancer Research: 63:4757-4762.
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Ruf W, Seftor EA, Prtrovan R, Weiss RM, Gruman LM, Margaryan NV, Seftor REB, Miyagi Y and Hendrix MJC (2003). Differential role of tissue factor pathway inhibitors-1 and 2 (TFPI-1 and 2) in melanoma vasculogenic mimicry. Cancer Research : 63:5381-5389.
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Chunthapong J, Seftor EA, Khalkhali-Ellis Z, Seftor REB, Amir S, Lubaroff DM, Heidger PM Jr. and Hendrix MJC (2003). Dual roles of E-cadherin in prostate cancer invasion. J Cellular Biochemistry: 91:649-661.
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Seftor EA, Meltzer PS, Kirschmann DA, Pe’er J, Maniotis AJ, Trent JM, Folberg R and Hendrix MJC (2002). Molecular determinants of human uveal melanoma invasion and metastasis. Clinical Experimental Metastasis: 19:233-246.
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Hendrix MJC, Seftor REB, Seftor EA, Gruman LM, Lee LML, Nickoloff BJ, Miele L, Sheriff DD and Schatteman GC (2002). Transendothelial function of human metastatic melanoma cells: Role of the microenvironment in cell-fate determination. Cancer Research: 62:665-668 (Cover Illustration).
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Seftor EA, Meltzer PS, Kirschmann DA, Pe’er J, Maniotis AJ, Trent JM, Folberg R and Hendrix MJC (2002). Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: Role of vasculogenic mimicry. Critical Reviews in Oncology/Hematology: 44:17-27.
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Seftor REB, Seftor EA, Kirschmann DA and Hendrix MJC (2002). Targeting the tumor microenvironment with chemically modified tetracyclines: Inhibition of laminin 5gamma2 chain promigratory fragments and vasculogenic mimicry. Molecular Cancer Therapeutics: 1:1173-1179.
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Seftor REB, Seftor EA, Gardner LMG, Bilban M, Koshikawa N, Trent J, Meltzer PS, Stetler-Stevenson WG, Quaranta V and Hendrix MJC (2001). Cooperative interactions of laminin 5 Gamma2, MMP-2 and MT1-MMP are required for mimicry of embryonic vasculo-genesis by aggressive melanoma. Cancer Research: 61:6322-6327 (Cover Illustration).
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Hendrix MJC, Seftor EA, Meltzer PM, Gardner LMG, Hess AR, Kirschmann DA, Schatteman GC and Seftor REB (2001). Expression and functional significance of VE-cadherin in aggressive melanoma cells: Role in Vasculogenic mimicry. Proceedings of the National Academy of Sciences: 98:8018-8023.
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Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M, Radmacher, Simon R, Yakhini Z, Ben-Dor A, Dougherty E, Pollock P, Dietrich K, Alberts D, Sondak V, Hayward N and Trent J (2000). Molecular classification of cutaneous malignant melanoma by gene expression: Shifting from a continuous spectrum to distinct biologic entities. Nature: 406:536-540.
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Awards/Honors
2006-2007 - Marquis Who’sWho in America Recipient, 75th Edition

2005-2006 - Marquis Who’sWho in Scienceand Engineering Recipient, 8th Edition

2004-2005 - Marquis Who’sWho in Medicine and Healthcare Recipient, 5th Edition.


Professional Service
2004 - Present Member, Society for Melanoma Research
2004 - Present Member, CMRC Biological and Chemical Safety Committee
2004 - Present Member, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University
1996 - Present Member, American Association for Cnacer Research
1997 - 2004 Member, The Holden Comprehensive Cancer Center at The University of Iowa Carver College of Medicine

Curriculum Vitae
Microsoft Word DOC View Microsoft Word DOC file of Elisabeth Seftor's CV.

Last Updated: Nov 15 2007 10:27AM

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