CMRC Children's Memorial Research Center
Profile


Angela R Hess
 Research Assistant Professor, Cancer Biology and Epigenomics Program



2300 Children's Plaza
Box 222 Room C.473
Chicago, IL 60614
Phone: (773) 755-6327
Fax: (773) 755-6594


Education
Year Degree Institution
2002 Ph.D. Department of Anatomy and Cell Biology, Univesity of Iowa, Iowa City, IA
1998 B.S. Microbiology Pennsylvania State University, University Park, PA

Work Experience
Period Description Organization
2004 - 2005 Research Scientist Children's Memoral Research Center, Chicago, IL
2002 - 2004 Postdoctral Fellow The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA

Research Interests
The incidence of cutaneous melanoma is on the rise. When melanoma is detected early and treated before metastasis occurs patient survival is favorable; however the 5 year survival rate for metastatic melanoma is dismal. One of the focuses of our laboratory is to understand the molecular mechanisms by which aggressive human melanoma cells are able to respond and adapt to their tumor/host microenviroment as a way to better understand how melanoma cells acquire a metastatic phenotype. My research interests involve understanding the signal transduction mechanisms which act to promote melanoma aggressiveness as characterized by increased invasion, migration and vasculogenic mimicry--or the unique ability of aggressive but not poorly aggressive melanoma cells to express endothelial markers and form embryonic-like tubular networks both in vitro and in vivo, thus allowing for a complementary means for tumor perfusion and metastasis. Understanding the signaling mechanisms which work to promote a more aggressive melanoma phenotype leading to metastasis will enable us to identify new targets for therapeutic intervention of aggressive melanoma.

Recent Publications
Hess, A.R, Seftor, E.A, Gruman, L.M, Kinch M.S, Seftor, R.E.B, and Hendrix, M.J.C. (2006). Ve-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry. Cancer Biology and Therapy: 224-233.

Hess, A.R, and Hendrix, M.J.C. (2006). Focal Adhesion Kinase signaling and the aggressive melanoma phenotype. Cell Cycle: 478-480.

Hess, A.R, Postovit, L.M, Seftor, E.A, Margaryan, N.V, Schneider, G.B, Seftor, R.E.B, and Hendrix, M.J.C. (2005). Focal Adhesion kinase promotes an aggressive melanoma phenotype. Cancer Research: 9851-9860.

Hess, A.R, Seftor, E.A, Seftor, R.E.B, Seftor, and Hendrix, M.J.C. (2003). Phosphoinositide 3-kinase regulates MT1-MMP and MMP-2 activity during melanoma vasculogenic mimicry. Cancer Research: 4757-4762.

Hendrix, M.J.C, Seftor, E.A, Hess, A.R, and Seftor, R.E.B. (2003). Vasculogenic Mimicry and tumour-cell plasticity: lessons from melanoma. Nature Cancer Reviews: 411-421.

Hess, A.R, Seftor, E.A, Gardner, L.M.G, Carles-Kinch, K, Schneider, G.B, Kinch, M.S, Seftor, R.E.B, and Hendrix M.J.C. (2001). Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase. Cancer Research: 3250-3255.

Maniotis, A.J, Folberg, R, Hess, A.R, Seftor, E.A, Gardner, L.M.G, Pe'er, J, Trent, J.M, Meltzer, P.S, and Hendrix, M.J.C. (1999). Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. American Journal of Pathology: 739-752.

Awards/Honors
2003 - Finalist for UMI Dissertation Award sponsored by the National Council of Graduate Schools

2003 - Received the D.C. Spriestersbach Dissertation Prize for Biological and Life Sciences, U. of Iowa

2002 - Received Travel Award from American Assoictiation of Anatomist to attend EB meeting

2001 - Selected to attend AACR special workshop; "Pathobiology of Cancer"

2000 - Received Tung-Yang Wing award for superior acheivement in Anatomy Graduate Education, U. of Iowa

1999 - Electron Microscopy Techniques presentation award, U. of Iowa

1997 - Recipient of Biochemistry and Molecular Biology Research Award; Pennsylvania State University


Curriculum Vitae
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Last Updated: Apr 5 2006 11:11AM

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