Aleksandra Glavaski-Joksimovic, PhD


galavski300
Laboratory of Dr. Martha Bohn
Neurobiology Program
2430 N. Halsted St. Rm C.321
Chicago, IL 60614

BS, University of Belgrade, Belgrade, Serbia
MS, University of Belgrade, Belgrade, Serbia
PhD, Iowa State University

I am working on a project which studies the potential use of stem cells in a novel therapy for Parkinson's disease (PD). In our studies we are using human mesenchymal stem cells (hMSC) obtained from bone marrow aspirates of young healthy adult volunteers and genetically modified with the intracellular domain of the Notch gene to generate SB623 cells. This modification results in expression of neuronal phenotypic markers as previously reported. We are studying whether SB623 cells can rescue dopaminergic neurons from neurotoxin induced cell death and deficits in dopamine-dependent behaviors in a rat model of PD. In addition we are exploring the potential of SB623 cells to deliver glial cell line-derived neurotrophic factor (GDNF) in a rat model of PD.

Publications:

Glavaski-Joksimovic A, Thonabulsombat C, Wendt M, Eriksson M, Palmgren B, Jonsson A, Olivius P. (2008) Survival, migration and differentiation of Sox-1-GFP embryonic stem cells in coculture with an auditory brain stem slice preparation. Cloning Stem Cells, 10:75-88.

Scanes CG, Glavaski-Joksimovic A, Johannsen SA, Jeftinija S, Anderson LL. (2007) Subpopulations of somatotropes with differing intracellular calcium concentration responses to secretagogues. Neuroendocrinology, 85: 221-231.

Scanes CG, Jeftinija S, Glavaski-Joksimovic A, Proudman J, Aramburo C, Anderson LL. (2005) The anterior pituitary gland: lessons from livestock. Domestic Animal Endocrinology, 29: 23-33.

Anderson LL, Jeftinija S, Scanes CG, Stromer MH, Lee JS, Jeftinija K, Glavaski-Joksimovic A. (2005) Physiology of ghrelin and related peptides. Domestic Animal Endocrinology, 29: 111-144.

Glavaski-Joksimovic A, Rowe EW, Jeftinija K, Scanes CG, Anderson LL. (2004) Effects of leptin on intracellular calcium concentrations in isolated porcine somatotropes. Neuroendocrinology, 80: 73-82.

Glavaski-Joksimovic A, Jeftinija K, Scanes CG, Anderson LL, Jeftinija S. (2003) Stimulatory effect of ghrelin on isolated porcine somatotropes. Neuroendocrinology, 77: 367-379.

Glavaski-Joksimovic A, Jeftinija K, Jeremic A, Anderson LL, Jeftinija S. (2002) Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes. Journal of Endocrinology, 175: 625-636.

Cho SJ, Jeftinija K, Glavaski A, Jeftinija S, Jena BP, Anderson LL. (2002) Structure and dynamics of the fusion pores in live GH-secreting cells revealed using atomic force microscopy. Endocrinology, 143: 1144-1148.

Jeremic A, Jeftinija K, Stevanovic J, Glavaski A, Jeftinija S. (2001) ATP stimulates calcium-depedent glutamate release from cultured astrocytes. Journal of Neurochemistry, 77: 664-675.

Plecas B, Glavaski A, Solarovic T, Savic V, Hristic M. (1998) The effects of isoproterenol on the adrenal cortex of adult male rats treated with ethane dimethanesulfonate. Arch. Toxicol. Kinet. Xenobiot. Metab., 6: 293-294.

Glavaski A, Solarovic T, Hristic M, Savic V, Plecas B. (1998) Isoproterenol partially prevents the ventral prostate regression in chemically castrated rats. Folia Anatomica, 26: 10-11.

Glavaski A, Solarovic T, Hristic M, Savic V, Plecas B. (1998) Ventral prostate structure and serum testosterone levels in rats with different androgen status after the chronic treatment with propranolol. Acta Vet. (Belgrade), 48: 79-88.

Plecas B, Glavaski A, Hristic M, Solarovic T. (1998) Ventral prostrate structure and serum testosterone levels after chronic treatment with isoproterenol in adult rats with different androgen status. Archives of Andrology, 35: 125-136.

Leposavic G, Plecas B, Karapetorovic B, Popovic A, Glavaski A. (1997) Morphometrical analysis of the thymus after orchidectomy or oxytocin treatment. Folia Anatomica, 25: 33-40.

Plecas B, Glavaski A, Savic V, Hristic M, Djuric D, Solarovic T. (1997) Effects of ethane dimethanesulfonate on the structure of adult amel rat adrenal cortex. Pharmacological Research, 35: 541-546.

Plecas B, Glavaski A, Solarovic T. (1997) Propranolol treatment affects ventral prostate blood vessels and serum testosterone concentrations in adult rats. Andrologia, 29: 109-114.

Plecas B, Popovic A, Glavaski A, Hristic M, Solarovic T. (1996) Stereologic study on the effect of prolonged urapidil-treatment on the rat ventral prostate. Acta Vet. (Belgrade), 46: 73-80.

Plecas B, Glavaski A, Djuric D, Hristic M, Solarovic T. (1996) Stereologic study on the effects of oxytocin and propranolol on the rat adrenal cortex. Yugoslav. Physiol. Pharmacol. Acta, 32: 223-228.

Popovic A, Plecas B, Ugresic N, Glavaski A. (1996) Altered gonadal hormone level and constant light-induced stress interfere with the response of the adrenal medulla to oxytocin. Brazilian Journal of Medical and Biological Research, 29: 273-280.

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