CMRC Children's Memorial Research Center
Elisabeth Seftor

Elisabeth A Seftor
 Director: NIH/NCI Tumor Microenvironment Training Course

Children's Memorial Research Center
2430 N. Halsted St Room 477
Chicago, IL 60614
Phone: (773) 755-6366
Fax: (773) 755-6594

Year Degree Institution
1975 Bachelor of Science in Cellular Molecular Biology California State University, Northridge

Work Experience
Period Description Organization
June 2004 - Present Senior Research Scientist, Children's Memorial Research Center Children's Memorial Hospital
August 1996 - May 2004 Senior Research Specialist Dept of Anatomy & Cell Biology University of Iowa
December 1993 - August 1996 Senior Research Associate, Pediatric Research Institute, Dept. of Pediatrics Saint Louis University
July 1983 - August 1993 Senior Research Specialist, Dept of Anatomy and Dept of Biochemistry University of Arizona
August 1977 - July 1983 Staff Research Associate II, Dept of Biology and Dept of Microbiology University of California, Los Angeles
July 1975 - June 1977 Staff Research Associate I, Dept of Microbiology & Immunology University of California, Berkeley

Research Interests
As part of the Mary Hendrix research team we have recently embarked on the classification and molecular profiling of tumors, especially cutaneous and ocular melanomas, based on differential gene expression (microarray analysis). Our findings based on the molecular signature of aggressive melanoma cells indicate the expression of multiple phenotypes, which appears to mimic a multi-potent, embryonic-like phenotype. One example of this tumor cell plasticity was seen in the ability of aggressive melanoma cells (but not poorly aggressive cells) to express endothelial cell-specific markers and participate in vasculogenic mimicry. The aggressive tumor cells also demonstrated the ability of deposit “molecular cues” into the basement membrane matrix of their environment that can subsequently induce poorly aggressive cells to participate in vasculogenic mimicry and express endothelial cell-specific markers. The observation that aggressive tumor cells can express multiple molecular phenotypes should lead to the development of new diagnostic markers and therapeutic targets for clinical intervention of cancer.

Research Funding
Title Funding Source Period Amount Duties
Epigenetic Effect of the Microenvironment on Stem Cell Plasticity and Function NIH/NCI 2007 - 2012 $1,224,400 Co-I
Endothelial Transdifferation of Invasive Tumor Cells NIH/NCI MERIT Award 2002 - 2012 $1,912,500 +2,008,700 Co-I
Biological Function(s) of Maspin NIH/NCI 2004 - 2009 $1,278,000 Co-I
Reversal of the Disease Progression by Stem Cells Illinois Regenerative Medicine Institute (IDPH) 2006 - 2008 $213,150 Co-I, Project 1
NCI-Sponsored Tumor Microenvironment Training Site: Techniques in the Establishment and Manipulation of Organotypic Model Systems NIH/NCI 2005 - 2007 $150,000 Co-I
Prostatic Vasculogenic Mimicry: A New Metastatic Pathway? NIH/NCI 2001 - 2005 $1,440,600 Co-I
Regulation of Uveal Melanoma Interconverted Phenotype NIH/NCI 1998 - 2004 $1,226,578 Co-I

Lab Affiliations