CMRC Children's Memorial Research Center
Stem Cell Transplantation

For information on the following Clinical Trials, please contact the
Hematology, Oncology and Stem Cell Transplantation Department
at 773-880-4562 during 8:30 AM to 5:00 PM Central Standard Time. 

  General Transplant Protocols:  Investigator
SCT 0193 General Bone Marrow/SCT Research Morris Kletzel, MD
     
  Allo Transplant Protocols: Investigator
SCT 0205 Reduced Intensity Stem Cell Transplant in Children and Young Adults Utilizing Photopheresis, Fludarabine and Busulfan David Jacobsohn, MD / Jennifer Schneiderman, MD
SCT 0208 Allogeneic Transplanation for Pediatric Leukemias with Unrelated Donors Using Fludarabine, Busulfan, 400 cGy Total Body Irradiation, and Thymogobulin David Jacobsohn, MD
SCT 0300-0406 Reduced Intensity Immunoablative Protocol for Allogeneic Related and Unrelated Hemotopoietic Peripheral Blood Stem Morris Kletzel, MD
SCT 0307 Full Intensity Myeloid & Lymphoid Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies Morris Kletzel, MD
SCT 0608 BMT CTN 0601: Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Sickle Cell Disease using a Reduced Intensity Conditioning Regimen Sonali Chaudhury, MD
SCT 0802 Fanconi’s Anemia Clinical Trial of Low-Dose TBI & Flu. Followed by Un. Donor SCT for Pts w/Fanconi Anemia Morris Kletzel, MD
SCT 0806 Palifermin Phase 1 Trial of Palifermin for Oral Mucositis Reggie Duerst, MD
ASCT0431 A Randomized Trial of Sirolimus-Based Graft versus Host Disease Prophylaxis after Hematopoietic Stem Cell Transplantation in Relapsed ALL David Jacobsohn, MD
   
  Auto Transplant Protocols: Investigator
SCT 0308 High dose temozolomide, thiotepa and carboplatin with autologous stem cell rescue (ASCR) followed by continuation therapy with 13-cis-retinoic acid in patients with recurrent/refractory maligant brain tumors Reggie Duerst, MD
SCT 0499 Solid Tumor High Dose Chemotherapy with Tandem Peripheral Blood Stem Cell Rescue for the Treatment of High Risk Pediatric Solid Tumors Morris Kletzel, MD
SCT 0707 Early Diagnosis and Stem Cell Transplantation for Severe Immunodeficiency Diseases (SCIDS) William Tse, MD
SCT 1007 Autoimmune Diseases A Pilot Study of High-Dose Immunosuppression Followed by Infusion of CD34-Selected Autologous or Syngeneic Peripheral Blood Stem Cells for Treatment of Refractory Autoimmune Disorders Reggie Duerst, MD
SCT 1202 Crohn's Disease Immune Ablation and Hematopoietic Stem Cell Support with Severe Crohn’s Disease Morris Kletzel, MD
     
  GVHD Protocols: Investigator
SCT 0703 ECP for aGVHD Extracorporeal Photopheresis for Steriod-Refractory Acute GVHD in Children: A Safety and Feasibility Study David Jacobsohn, MD
SCT 0108 Chronic GVHD Natural History Cohort Study David Jacobsohn, MD
SCT 0208b Development and Validation of a Symptoms Scale for Children with Chronic Graft Versus Host Disease David Jacobsohn, MD
SCT 0708 Expanded Access of ProchymalTM (Ex-vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Pediatric Patients who have failed to respond to steriod treatment for acute GVHD Sonali Chaudhury, MD
     
  Supportive Care Protocols: Investigator
SCT 0805 IFI Invasive Fungal Infection Registry Morris Kletzel, MD
SCT 1006 Defibrotide Defibrotide for the Treatment of severe Veno-Occlusive Disease (Amend 3.0) Reggie Duerst, MD

SCT 0407 Markers of Inflammation-----(Not Accruing New Patients)

 Markers of Inflammation in Hematopoietic Stem Cell Transplant (Amend 2.0)

David Jacobsohn, MD
ASCT0521 Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Acute, Non-infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) David Jacobsohn, MD
SCT 0408B Defibrotide for HSCT Patient with Severe Hepatic VOD: A Treatment  IND Study Reggie Duerst, MD
SCT 1107 Polymorphism and Busulfan PK's Morris Kletzel, MD
     
Other Stem Cell Protocols: Investigator
SCT 0599 Procurement of Umbilical Cord Hematopoietic Stem Cells (UCHSC) for Laboratory Research Purposes Morris Kletzel, MD
SCT 1207D NMDP & CIBMTR Research Protocol for a Research Database for Hematopoietic Stem Cell Transplantation and Marrow Toxic Injuries Reggie Duerst, MD
SCT1207R NMDP Protocol for a Research Sample Repository for Allogeneneic Hematopoietic Stem Cell Transplantation Reggie Duerst, MD
ASCT0631 A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source in Matched Sibling Donor Transplantation David Jacobsohn, MD