Research news (InTouch Summer 2008)

Karen GouzeRichard WendelThe integrative, module-based family treatment model (IMBFT) developed by Karen R. Gouze, PhD, and Richard Wendel, DMin, provides a formalized series of steps that clinicians can use in their case planning and implementation. It is based on nine clinically relevant modules for assessment and intervention that are consistent with current best practices and empirically supported treatments. IMBFT guides therapists in considering assessment issues relevant to child, adolescent, adult and family functioning. This process allows therapists to access and integrate evidence-based methods within a comprehensive treatment plan that is sensitive to both the art of clinical judgment and the developing science of family therapy.

The model was published in The Journal of Marital and Family Therapy in 2005. In the July 2008 issue, the model will be interpreted for application in the clinical setting. A workshop will be presented at the annual meeting of the American Academy of Child and Adolescent Psychiatry in October.

Gouze is associate professor of Psychiatry and Behavioral Sciences at the Feinberg School and director of Training in Psychology at Children’s Memorial. Wendel is assistant professor of Psychiatry and Behavioral Sciences at the Feinberg School, allied health professional at Children’s Memorial, and adjunct faculty of the Family Institute at Northwestern University.

Zoe N. Demou, PhD, has published a study in the journal Biotechnology and Bioengineering describing a novel technique for studying morphological and molecular dynamics in differentiating 3D cell cultures. A custom-built chamber expands the Veritas laser capture microdissection (LCM) system by enabling time-lapse image acquisition for morphological and topographical mapping of cell cultures. For the first time, LCM was performed on live cells in 3D gels, and compatibility with genomics and proteomics was demonstrated. Pre-selecting cell targets immersed in their culture media minimizes microdissection time and stress to produce biomolecules of optimum quality and biological relevance. Methods that induce and direct stem cells to desired tissue-specific lineages hold promise for treatments that could enable the body to repair, restore and regenerate damaged or diseased cells, tissues and organs. The key to these innovative therapies is to harness the molecular mechanisms that control cellular processes and commitment to specific lineages. This technique provides a discovery tool for probing the dynamics of cellular plasticity.

Demou is research assistant professor of Pediatrics at the Feinberg School and a member of the Developmental Biology Program of the research center.

Ram Yogev

May 11 (Chicago Tribune)- Giovanna Breu’s feature story, "Growing up with HIV," discusses the experiences of children and teenagers who were born with or acquired the disease at an early age. In the story, Ram Yogev, MD, Susan B. DePree Founders’ Board Professor of Pediatric, Adolescent and Maternal HIV Infection at the Feinberg School, medical director of Pediatric and Maternal HIV Infection at Children’s Memorial, and Deputy Director for Research - Clinical Sciences at the research center, commented on the tremendous advances in HIV care and treatment. "Instead of going to funerals, I am going to graduations and weddings," he said. Robert Garofalo, MD, MPH, who directs adolescent HIV services at Children’s Memorial, called children born with HIV "a forgotten group" that does not have many peer groups. These young adults struggle with relationships, autonomy from parents and their emerging sexuality.

Catherine Webb

April 21, 2008 - The American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing have issued a statement about cardiovascular evaluation and monitoring of children receiving drugs to treat Attention Deficit Hyperactivity Disorder (ADHD). The councils recommend carefully assessing children for heart conditions; obtaining a patient and family health history and doing a physical exam focused on cardiovascular disease risk factors before treatment; acquiring an electrocardiogram (ECG), although treatment should not be withheld because an ECG is not done; and monitoring heart rate and blood pressure in children with heart conditions taking these drugs.

Catherine Webb, MD, chair of the AHA council, is professor of Pediatrics at the Feinberg School and a pediatric cardiologist at Children’s Memorial.

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