CMRC Children's Memorial Research Center
Research News

Research News

InTouch Winter 2008 (Volume 4: Issue 4)

October 29, 2007 (HealthDay News, Washington Post) — The American Academy of Pediatrics (AAP), has issued a statement that the emergency defibrillators that have saved thousands of adult cardiac arrest victims can also safely be used on children younger than 8 years old. Steven E. Krug, MD, chairman of the academy’s Committee on Pediatric Emergency Medicine, head of the Division of Pediatric Emergency Medicine at Children’s Memorial Hospital and Professor of Pediatrics at Northwestern University's Feinberg School of Medicine, said “There has been an advance in the technology. Even in a situation where you can provide only an adult dose, that still may be better than doing nothing.” As with adults, defibrillation of children experiencing a problem must be done quickly. “Time is of the essence,” Krug said. “As time passes, the chance of resuscitation decreases rapidly.” The likelihood of survival decreases by seven to 10 percent with each minute of delay to defibrillation after cardiac arrest, the AAP statement said.
November 5, 2007 (U.S. News & World Report)
— New research has found a strong correlation between a child’s weight and the amount of sleep that child gets. The study, published in the November 2007 issue of the journal Pediatrics, found that sixth-graders who averaged less than 8.5 hours of sleep a night had a 23 percent rate of obesity, while their well-rested peers who averaged more than 9.25 hours of sleep had an obesity rate of just 12 percent. Stephen Sheldon, MD, director of the Sleep Medicine Center at Children’s Memorial, said “Pediatricians and parents really need to start paying closer attention to sleep-wake habits. In this society, we put a premium on being awake, and that premium may hurt us in the long run.” Sheldon is also Professor of Pediatrics at the Feinberg School.
November 17, 2007 (ScienceDaily)Xiao-Di Tan, MD, and colleagues in the Center for Digestive Diseases and Immunobiology have identified a crucial role for MFG-E8, a component of human breast milk. The protein is important in the maintenance and repair of the intestinal lining in rats and mice. In a wound-healing experiment with cultured rat intestinal epithelial cells, treatment with MFG-E8 improved migration to the site of injury. Additionally, depletion of this protein in mice resulted in decreased intestinal migration and localized injury of the intestinal lining. In septic mice with widespread infection due to puncture of the large intestine, treatment with MFG-E8 improved intestinal cell migration, whereas depletion prolonged healing time. These data suggest that MFG-E8 might be useful for the treatment of individuals with bowel injuries. Tan and colleagues published their results in the December 2007 issue of The Journal of Clinical Investigation. Tan is Associate Professor of Pediatrics at the Feinberg School, and the Eloise and Warren Batts Research Scholar in the Molecular and Cellular Pathobiology Program at the research center.
January 16, 2008 (U.S. News & World Report) — A study has found that the drug etanercept significantly improved psoriasis symptoms in children under 17 with moderate to severe psoriasis. 57 percent of the children and teens enrolled in the study had at least a 75 percent improvement in their symptoms, and their quality of life also improved. “Psoriasis is not just some benign skin disease but can be truly life-altering for patients,” said the study’s lead author, Amy Paller, MD, attending physician in the Division of Dermatology at Children’s Memorial, and chair of Dermatology at the Feinberg School. “In our study, etanercept positively impacted quality of life,” added Paller. To assess the drug’s safety and efficacy in children under 17, Paller and colleagues recruited 211 children and adolescents with moderate to severe psoriasis. The researchers chose etanercept because it’s already being used to treat children with juvenile rheumatoid arthritis and appears to be safe in that population.
February 12, 2008 (Chicago Sun-Times) — A new study published in the Journal of Allergy and Clinical Immunology indicates that geography may have an impact on whether you develop asthma. Ruchi Gupta, MD, MPH, Assistant Professor of Pediatrics at the Feinberg School, and colleagues at the Mary Ann & J. Milburn Smith Child Health Research Program and other institutions, report that while race, gender, age and genetics do play a role, these are not enough to account for huge differences in asthma rates found in adjacent neighborhoods. Several factors appear to trigger asthma in kids, including air pollution, exposure to dust mites and cockroaches, obesity and diets low in antioxidants. Many children with asthma also live with smokers. The research was based on a survey of nearly 49,000 Chicago public school students.