Topczewski Laboratory

Recent Awards

July 2010 - Jorge Cantu, graduate student in the NUIN program, received individual F31 National Research Service Award form NIH/National Institute of Neurological Disorder and Stroke.toplab2010The Topczewski laboratory investigates the mechanisms that control the morphogenetic processes of vertebrate embryos, by using zebrafish as a model. Similarities in developmental programs among all vertebrates make zebrafish an excellent model for studying human diseases and development. In our work we utilize a combination of genetic analysis with embryological and molecular methods uniquely available in zebrafish. Our long-term goal is the identification of signaling pathways that will suggest novel candidate genes involved in human congenital abnormalities and diseases.

  • Recent Publications

    Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW. (April 2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 28;5:e10367.

    LeClair EE, Topczewski J, (January 2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair.  PLoS ONE 5: e8737.

    Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon H-G (January 2010). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.  Dev Biol 15;337:233-345. Epub 2009 Nov 3

    Leclair EE, Topczewski J (November 2009) Methods for the study of the zebrafish maxillary barbel.  JoVE 23;(33). pii: 1558.

    Topczewski J and Solnica-Krezel L. (September 2009). Cytoskeletal dynamics of the zebrafish embryo. Essential zebrafish methods: Cell and developmental biology. Reliable Lab Solutions Series. Elsevier Inc. pp 133-157

    LeClair EE, Mui S, Huang A, Topczewska JM, Topczewski J (September 2009) Craniofacial skeletal defects of adult zebrafish glypican 4 (knypek) mutants.  Dev Dynamics 238(10):2550-2563

    Sisson BE and Topczewski J (October 2009). Expression of five frizzleds during zebrafish craniofacial development.  GEP: 520-7

    Drerup CM, Wiora HM, Topczewski J, Morris JA. (August, 2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development: 136(15): 2623-2632

    Dale RM, Sisson BE, Topczewski J. (March, 2009). The Emerging Role of Wnt/PCP Signaling in Organ Formation.  Zebrafish 6:9-14












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